We seem to have found a solution for Charlie! We started the new formula last Thursday and it seems to have made a world of difference. He is less fussy and gassy, less irritable, and is sleeping better. Today he actually took a long nap, over 2 hours! That is the longest stretch he has slept since birth. His reflux is much better on the zantac, he is no longer screaming in pain daily and seems to be spitting up very rarely. He is smiling and cooing much more often and I feel like he is finally showing us who he really is. I am so happy we were able to find ways to make him more comfortable. I hated seeing him so miserable!